Studies on Xarelto
A study reported in 2015 in JAMA Ophthalmology found that patients in their 70’s and 80’s, who transferred from warfarin to Xarelto, were prone to vitreous hemorrhaging, or bleeding between the lens and retina of the eye.
A second study published in 2015 in BMJ reported that it could not rule out a twofold higher risk of stomach bleeding in patients who were taking Xarelto in comparison to warfarin. The study included nearly 46,000 people.
Several studies have also indicated that patients over the age of 65 were suffering the majority of bleeds linked to Xarelto. In fact, a study presented in 2015 found that 74% of bleeding occurred in those 75 years or older.
Xarelto was shown to increase bleeding risk by 25 percent when compared to warfarin in four phase III trials.